Sodium/potassium proportion change is actually with the hypertension transform: probability of population method for sodium/potassium proportion reduced wellness checkup

Sodium/potassium proportion change is actually with the hypertension transform: probability of population method for sodium/potassium proportion reduced wellness checkup

Recently, the sodium (Na)/potassium (K) ratio was reported to be associated with blood pressure (BP). A Na/K ratio self-monitoring device using spot urine was established recently. Here, we assessed whether the urinary Na/K ratio change measured using the Na/K device was associated with BP change in a health checkup setting. We targeted 12,890 participants who attended the health checkup in Tome City, Miyagi between 2017 and 2018. Tome City introduced urinary Na/K ratio measurements during health checkups since 2017. For each year, we compared the baseline characteristics according to the urinary Na/K ratio and BP level. We assessed the relationship between change in urinary Na/K ratio and BP change using multiple regression analyses adjusted for age, sex, and change in body mass index (BMI) and alcohol intake. The average urinary Na/K ratio was significantly lower in 2018 than in 2017 (5.4 ± 3.0 to 4.9 ± 2.2, P < 0.01). The systolic BP of the participants in 2018 (130.9 ± 17.4 mmHg) was lower than that in 2017 (132.1 ± 17.9 mmHg). Moreover, the change in systolic BP and diastolic BP was positively associated with the change in urinary Na/K ratio. In conclusion, the association of the change in urinary Na/K ratio with hypertension and changes in systolic and diastolic BP can be explained by a change in alcohol intake, BMI, and urinary Na/K ratio. Therefore, measuring the urinary Na/K ratio in community settings is a potential population approach for counteracting hypertension.


Has just, it absolutely was stated that the newest salt (Na)/potassium (K) ratio is regarding the blood circulation pressure (BP) within the a mix-sectional studies [1,2,3,4]. This is certainly asked because highest Na and K intake is understood to-be connected with higher and you can low BP, correspondingly [5,6,7]. While doing so, research has already been held toward source thinking and you can things adding to the latest Na/K ratio before year [8, 9].

Sodium/potassium proportion transform are of hypertension changes: chances of populace approach for sodium/potassium proportion lack of fitness checkup

When you look at the a residential area means, it is hard for us to evaluate the real Na consumption since the Na intake are traditionally assessed because of the twenty-four-h pee collection. Even though numerous equations getting estimating Na intake or K consumption having fun with informal room urine was indeed recently established, such equations aren’t direct sufficient to provide opinions into the people [10,11,12]. Additionally, since the equation need measuring Na, K, and you may creatinine membership when you look at the a lab, it will require many weeks to discover the results for someone. Even in the event participants are aware that salt reduction is good for lowering BP, he has got not a way out of examining the Na top.

Recently, a great Na/K ratio worry about-keeping track of equipment playing with put pee was situated . Though it didn’t measure the genuine Na consumption height, it can render feedback about your urinary Na/K balance within minutes. More over, a keen interventional otherwise observational studies with this particular display advised that this was a good product so you’re able to imagine the urinary Na/K proportion [thirteen, 14].

For this reason, while we don’t have any treatment for assess the Na/K proportion in the wellness checkup options, i believed that assessing the newest urinary Na/K ratio from inside the a health checkup webpages may have the potential to provide feedback into the general inhabitants about their Na/K proportion that will have an impact on feeling transform, improvement in action, Na/K ratio cures, and you may BP reduction. Within this study, we examined whether the urinary Na/K proportion alter mentioned towards Na/K proportion measurement device are for the BP changes separate off confounding activities eg bmi (BMI) alter and change inside the liquor intake and you can opposed brand new BP height and you can urinary Na/K proportion from the neighborhood peak.